- Titel
- Serum and Urinary Matrix Metalloproteinase-9 Concentrations in Dehydrated Horses
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-1009399
- Quellenangabe
- Animals
Erscheinungsjahr: 2023
Jahrgang: 13
Heft: 24
Seiten: 1-8
E-ISSN: 2076-2615 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Kidney disease is difficult to diagnose since available laboratory parameters only increase later in time. Matrix metalloproteinase-9 is an enzyme found in renal tissue and increased in human kidney disease. This study evaluated serum MMP-9 (sMMP-9) and urinary MMP-9 (uMMP-9) concentrations in dehydrated horses. Horses with signs consistent with dehydration and four healthy clinic-owned horses were included. Blood and urinary samples for MMP-9 measurements were collected at admission, and after 12 h, 24 h, and 48 h. Furthermore, the serum creatinine, urea, symmetric dimethylarginine (SDMA), urine-specific gravity, urinary protein concentration, fractional sodium excretion, and urinary gamma–glutamyl transferase/creatinine ratio (uGGT/Cr) were mea- sured. Statistical analysis included a repeated measures ANOVA and mixed linear regression model. Overall, 40 dehydrated horses were included (Acute kidney injury 1/40; elevated serum creatinine 7/40; elevated serum SDMA 11/40; elevated uGGT/Cr at presentation 5/28). In dehydrated horses, sMMP-9 concentrations were significantly higher on arrival compared to 12 h, 24 h, and 48 h. In healthy horses, sMMP-9 showed no differences over time or compared to patients. Urinary casts and uGGT/Cr correlated with sMMP-9. Serum urea was associated with uMMP-9/Cr. In conclusion, sMMP-9 was elevated at arrival in dehydrated patients compared to later measurements. Correlations to uGGT/Cr and urinary casts need further evaluation.
- Andere Ausgabe
- Erstveröffentlichung
DOI: 10.3390/ani13243776
Link: https://www.mdpi.com/2076-2615/13/24/3776 - Freie Schlagwörter (EN)
- matrix metalloproteinase, biomarker, renal function, dehydration, gelatinase B, equine kidney disease, MMP-9, dehydration
- Klassifikation (DDC)
- 590
- Verlag
- MDPI, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-1009399
- Veröffentlichungsdatum Qucosa
- 10.12.2025
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Deutsch
- Lizenz / Rechtehinweis
CC BY 4.0