- Titel
- Diabetes Mellitus as a negative prognostic factor in patients with brain metastases treated with radiotherapy
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-1021394
- Datum der Einreichung
- 31.03.2025
- Datum der Verteidigung
- 09.12.2025
- Abstract (EN)
- Cerebrovascular disorders are common among cancer patients. They might influence tumor growth, treatment sensitivity and, ultimately, the prognoses of patients with brain metastases (BM). In a retrospective exploratory study, we examined if the presence of arterial hypertension, smoking, diabetes mellitus (DM), hypercholesterolemia or peripheral arterial occlusive disease has a prognostic impact in patients with BM. In uni- and multivariate analysis, the presence of DM was associated with a worse prognosis across several tumor types, while for the other cerebrovascular risk factors, significant differences in survival were not found. From molecular data, it can be hypothesized that RAGE activation plays an important role in the interaction between DM and BM. In future studies, it remains to be determined to what extent serum glucose levels and antidiabetic treatments may influence survival and if optimized antidiabetic treatment or RAGE targeted treatments are able to improve prognoses of patients with BM.
- Andere Ausgabe
- Diabetes Mellitus Is a Strong Independent Negative Prognostic Factor in Patients with Brain Metastases Treated with Radiotherapy
DOI: 10.3390/cancers15194845 - Freie Schlagwörter (DE)
- brain metastasis, diabetes mellitus
- Klassifikation (DDC)
- 610
- Den akademischen Grad verleihende / prüfende Institution
- Universität Leipzig, Leipzig
- Version / Begutachtungsstatus
- aktualisierte Version
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-1021394
- Veröffentlichungsdatum Qucosa
- 09.02.2026
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Englisch
- Deutsch
- Lizenz / Rechtehinweis
CC BY-NC-ND 4.0