- Titel
- Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration
- Untertitel
- A transdiagnostic study cross-validating atrophy and fluid biomarkers
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-1032535
- Quellenangabe
- Alzheimer's & dementia : the journal of the Alzheimer's Associatio
Erscheinungsjahr: 2024
Jahrgang: 20
Heft: 7
Seiten: 4461-4475
ISSN: 1552-5260
E-ISSN: 1552-5279 - Erstveröffentlichung
- 2024
- Abstract (EN)
- INTRODUCTION: Frontotemporal lobar degeneration (FTLD) encompasses behav- ioral variant frontotemporal dementia (bvFTD), progressive supranuclear palsy, corticobasal syndrome/degeneration, and primary progressive aphasias (PPAs). We cross-validated fluid biomarkers and neuroimaging. METHODS: Seven fluid biomarkers from cerebrospinal fluid and serum were related to atrophy in 428 participants including these FTLD subtypes, logopenic variant PPA (lvPPA), Alzheimer’s disease (AD), and healthy subjects. Atrophy was assessed by structural magnetic resonance imaging and atlas-based volumetry. RESULTS: FTLD subtypes, lvPPA, and AD showed specific profiles for neurofilament light chain, phosphorylated heavy chain, tau, phospho-tau, amyloid beta1-42 from serum/cerebrospinal fluid, and brain atrophy. Neurofilaments related to regional atro- phy in bvFTD, whereas progranulin was associated with atrophy in semantic variant PPA. Ubiquitin showed no effects. DISCUSSION: Results specify biomarker and atrophy patterns in FTLD and AD supporting differential diagnosis. They identify neurofilaments and progranulin in interaction with structural imaging as promising candidates for monitoring disease progression and therapy.
- Andere Ausgabe
- Erstveröffentlichung
DOI: 10.1002/alz.13863
Link: https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.13863 - Freie Schlagwörter (EN)
- amyloid, atrophy, fluid biomarkers, frontotemporal dementia, frontotemporal lobar degeneration
- Klassifikation (DDC)
- 610
- Verlag
- Elsevier, New York, NY [u.a.]
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-1032535
- Veröffentlichungsdatum Qucosa
- 19.03.2026
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
