- Titel
- Prospective evaluation of S100A12 and S100A8/A9 (calprotectin) in dogs with sepsis or the systemic inflammatory response syndrome
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-840405
- Quellenangabe
- Journal of Veterinary Diagnostic Investigation
Erscheinungsjahr: 2019
Jahrgang: 31
Heft: 4
Seiten: 645-651
ISSN: 1943-4936 - Erstveröffentlichung
- 2019
- Abstract (EN)
- Pattern recognition receptors (e.g., S100A12 or S100A8/A9) hold promise as inflammatory biomarkers. We prospectively determined and compared serum S100A12 and S100A8/A9 concentrations in dogs with sepsis (n = 11) or systemic inflammatory response syndrome (SIRS; n = 8) over a 3-d period with each other, healthy controls (n = 50), and other clinical and clinicopathologic variables. Serum S100A12 and S100A8/A9 concentrations were significantly higher in dogs with sepsis or SIRS (all p < 0.05) at the time of hospital admission (day 1) compared to healthy controls, with no differences between patient groups. However, septic dogs had significantly lower serum S100A12 concentrations on day 2 and day 3 (both p < 0.05) compared to dogs with SIRS. Likewise, dogs with sepsis had significantly lower S100A8/A9 concentrations on day 2 (p < 0.05). Neither serum S100A12 nor S100A8/A9 concentrations were associated with survival to discharge. Our results suggest a differential expression of the S100/calgranulins between dogs with sepsis and those with SIRS. Serum S100A12 or S100A8/A9 concentration at the time of hospital admission did not differentiate dogs with sepsis from those with SIRS, but the trend of S100/calgranulin concentrations during the following 24–48 h may be a useful surrogate marker for differentiating sepsis from SIRS.
- Andere Ausgabe
- Link zur Erstveröffentlichung
Link: https://doi.org/10.1177/1040638719856655 - Freie Schlagwörter (EN)
- biomarker, calgranulin, canine, damage-associated molecular pattern, outcome, survival, systemic inflammatory response syndrome
- Klassifikation (DDC)
- 599
- Verlag
- Sage Publications, Thousand Oaks
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-840405
- Veröffentlichungsdatum Qucosa
- 09.03.2023
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Deutsch
- Lizenz / Rechtehinweis
