- Titel
- FDG PET correlates weakly with HIF-1a expression in solid tumors
- Untertitel
- a meta-analysi
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-840617
- Quellenangabe
- Acta Radiologica
Erscheinungsjahr: 2021
Jahrgang: 62
Heft: 4
Seiten: 557-564 - Erstveröffentlichung
- 2021
- Abstract (EN)
- Background: Hypoxia-inducible factor (HIF)-1a plays a key role in hypoxic adaptation of tumor cells. Overexpression of HIF-1a is associated with tumor aggressiveness and worse prognosis in several malignancies. Presumably, expression of HIF-1a may be reflected by positron emission tomography with 2-deoxy-2 [fluorine-18] fluoro-D-glucose (18F-FDG PET). There are inconsistent data about relationships between FDG PET and HIF-1a. Purpose: To provide evident data about associations between maximum standardized uptake value (SUVmax) and HIF-1a expression in solid tumors. Material and Methods: MEDLINE, SCOPUS, and EMBASE databases were screened for relationships between SUV and HIF-1a up to August 2019. Overall, 21 studies with 1154 patients were identified. The following data were extracted from the literature: authors; year of publication; number of patients; and correlation coefficients. Results: Correlation coefficients between SUVmax and HIF-1a were in the range of 0.51–0.71. The pooled correlation coefficient was 0.27 (95% confidence interval [CI] ¼ 0.14–0.41). Furthermore, correlation coefficients for some tumor entities were calculated. For this sub-analysis, data for primary tumors with >2 reports were included. The calculated correlation coefficients in the analyzed subgroups were as follows: head and neck squamous cell carcinoma: q ¼ 0.25 (95% CI ¼ 0.07–0.42); non-small lung cell cancer: q ¼ 0.27 (95% CI ¼ 0.14–0.67); uterine cervical cancer: q ¼ 0.09 (95% CI ¼ 0.89–0.71); thymic tumors: q ¼ 0.39 (95% CI ¼ 0.04–0.58). Conclusion: SUVmax of FDG PET correlated weakly with expression of HIF-1a both in overall sample and tumor subgroups. Therefore, FDG PET cannot be used for prediction of hypoxia in clinical practice
- Andere Ausgabe
- Link zur Erstveröffentlichung
Link: https://dx.doi.org/10.1177/0284185120932378 - Freie Schlagwörter (EN)
- FDG PET, hypoxia-inducible factor-1a, HIF-1a
- Klassifikation (DDC)
- 610
- Verlag
- SAGE Publications, Thousand Oaks
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-840617
- Veröffentlichungsdatum Qucosa
- 13.03.2023
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
