- Titel
- Procoagulant Extracellular Vesicles Alter Trophoblast Differentiation inMice by a Thrombo-InflammatoryMechanism
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-901253
- Quellenangabe
- International Journal of Molecular Sciences
Erscheinungsjahr: 2021
Jahrgang: 22
Heft: 18
Artikelnummer: 9873 - Erstveröffentlichung
- 2021
- Abstract (EN)
- Procoagulant extracellular vesicles (EV) and platelet activation have been associated with gestational vascular complications. EV-induced platelet-mediated placental inflammasome activation has been shown to cause preeclampsia-like symptoms in mice. However, the effect of EV-mediated placental thrombo-inflammation on trophoblast differentiation remains unknown. Here, we identify that the EV-induced thrombo-inflammatory pathway modulates trophoblast morphology and differentiation. EVs and platelets reduce syncytiotrophoblast differentiation while increasing giant trophoblast and spongiotrophoblast including the glycogen-rich cells. These effects are plateletdependent and mediated by the NLRP3 inflammasome. In humans, inflammasome activation was negatively correlated with trophoblast differentiation marker GCM1 and positively correlated with blood pressure. These data identify a crucial role of EV-induced placental thrombo-inflammation on altering trophoblast differentiation and suggest platelet activation or inflammasome activation as a therapeutic target in order to achieve successful placentation.
- Andere Ausgabe
- Link zur Erstveröffentlichung
DOI: 10.3390/ijms22189873 - Freie Schlagwörter (EN)
- thrombo-inflammation, extracellular vesicles, inflammasome, trophoblast differentiation
- Klassifikation (DDC)
- 610
- Verlag
- MDPI, Basel
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-901253
- Veröffentlichungsdatum Qucosa
- 26.02.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0