- Titel
- Biophysical Modeling of Transcranial Magnetic Stimulation Effects on Motor and Cognitive Brain Functions
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-991755
- Datum der Einreichung
- 17.03.2025
- Datum der Verteidigung
- 17.07.2025
- Abstract (EN)
- Transcranial magnetic stimulation (TMS) is a neurostimulation technique capable of temporarily modulating brain activity in healthy individuals and patients, without major discomfort. A key feature of TMS is that it allows excitation or inhibition of neural tissue non-invasively through the skull, enabling researchers to make causal inferences about the functions of cortical areas. This PhD thesis, consisting of four chapters, explores the effects of TMS on brain functions through biological modeling of the TMS-induced electric field (E-field). It aims to address fundamental challenges in understanding the mechanisms underlying TMS and its application to brain mapping. Chapter 1 provides an overview of TMS, detailing its mechanisms, applications, and current modeling approaches for understanding TMS-induced effects. Chapter 2 focuses on improving the precision of TMS-based motor cortex mapping by incorporating neuronal excitability into localization models. It is one of the first to apply and validate cortical-layer-specific modeling of TMS effects on motor cortex responses. Chapter 3 pioneers the TMS mapping methodology in the domain of spatial attention, offering a novel way to understand the neural mechanisms underlying attentional processes better. Finally, Chapter 4 concludes the thesis with a synthesis of the main findings, a discussion of their implications, and perspectives on future directions in TMS research.
- Andere Ausgabe
- Modeling the effects of transcranial magnetic stimulation on spatial attention
DOI: 10.1088/1361-6560/acff34 - Freie Schlagwörter (EN)
- Transcranial magnetic stimulation
- Electric field simulation
- TMS mapping
- Klassifikation (DDC)
- 570
- Den akademischen Grad verleihende / prüfende Institution
- Universität Leipzig, Leipzig
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-991755
- Veröffentlichungsdatum Qucosa
- 22.09.2025
- Dokumenttyp
- Dissertation
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0