- Titel
- Cognition in patients with neuromyelitis optica spectrum disorders
- Untertitel
- A prospective multicentre study of 217 patients (CogniNMO-Study)
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-992270
- Quellenangabe
- Multiple sclerosis journal
Erscheinungsjahr: 2023
Jahrgang: 29
Heft: 7
Seiten: 819-831
E-ISSN: 1477-0970 - Erstveröffentlichung
- 2023
- Abstract (EN)
- Background: There is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD). Objective: To assess cognitive performance and changes over time in NMOSD. Methods: This study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (N = 157). Intraindividual cognitive performance at 1- and 2-year follow-up was analyzed. Cognitive test scores were correlated with demographic and clinical variables and assessed with a multiple linear regression model. Results: NMOSD patients were impaired in SDMT (p = 0.007), MuSIC semantic fluency (p < 0.001), and MuSIC congruent speed (p < 0.001). No significant cognitive deterioration was found at follow-up. SDMT scores were related to motor and visual disability (pBon < 0.05). No differences were found between aquaporin-4-IgG-seropositive and double-seronegative NMOSD. Conclusions: A subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.
- Andere Ausgabe
- Erstveröffentlichung
Link: https://journals.sagepub.com/doi/10.1177/13524585231151212 - Freie Schlagwörter (EN)
- Neuromyelitis optica spectrum disorders, neuroimmunology, cognition, cognitive neuropsychology
- Normschlagwörter (GND)
- 610
- Verlag
- Sage, London
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-992270
- Veröffentlichungsdatum Qucosa
- 24.09.2025
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
CC BY 4.0