- AutorIn
- Malisa Sarntinoranont
- Thomas H. Mareci
- Titel
- Modeling direct injection of drugs into the brain
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-380502
- Quellenangabe
- Diffusion fundamentals - 32
Erscheinungsjahr: 2019
Jahrgang: 32
Artikelnummer: 6 - Erstveröffentlichung
- 2019
- Abstract (EN)
- The World Health Organization (WHO) estimates that one billion people worldwide suffer from central nervous system (CNS) disorders [1]. One major issue in treating these disorders is inadequate drug penetration which can be attributed to an effective blood-brain-barrier that limits passage across blood vessels. Low diffusivity of large classes of drug compounds restricts transport across blood vessel walls and subsequent passage through surrounding brain tissues. Tissue transport is emerging as an increasingly important area of research in drug delivery since the vast majority of therapeutic agents must traverse this space before reaching their targets.
- Freie Schlagwörter (EN)
- diffusion, central nervous system, CNS, brain
- Klassifikation (DDC)
- 530
- Version / Begutachtungsstatus
- angenommene Version / Postprint / Autorenversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-380502
- Veröffentlichungsdatum Qucosa
- 30.01.2020
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis